Smart specialization strategies (RIS3) have exploded in number across Europe over the past couple of years, among others due to the European Commission’s sustained effort – both conceptual and at the level of policy – to push this notion forward. What lies beneath the spate of recent RIS3s, in terms of specialization options as well as of the processes through which the latter were reached, is only now beginning to be examined in depth. Notably, the Commission did not offer a proper blueprint for RIS3-making, but opted instead to suggest a wide range of possible instruments. Based on our experience with the Romanian strategy-building process, in this article we outline a foresight-based toolkit for smart specialization and entrepreneurial discovery, though we too stop short of proposing a detailed full-fledged blueprint.